长非编码RNA和JAK/STAT信号通路调节在结直肠癌的发展
Abdolmajid Ghasemian1, Hadeel A Omear2, Yaser Mansoori1
1Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Frontiers in genetics
|December 14, 2023
概括
长非编码RNAs (lncRNAs) 通过调节Janus激酶/信号转换器和转录激活器 (JAK/STAT) 途径影响结肠直肠癌 (CRC). 了解这种交叉通话提供了新的CRC诊断和治疗的潜力.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 结肠直肠癌 (CRC) 仍然是癌症死亡的一个重要原因.
- 细胞信号通路,包括Janus酶/信号转换器和转录激活器 (JAK/STAT),对于基因表达和细胞生长至关重要.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在细胞过程和癌症发展中的调节作用,将它们定位为潜在的生物标志物.
研究的目的:
- 阐明lncRNAs与结直肠癌中的JAK/STAT信号通路之间的复杂关系.
- 探索lncRNAs如何调节JAK/STAT信号,以影响CRC进展,包括细胞增殖,入侵和免疫反应.
- 整合现有的体外和体内数据,通过JAK/STAT提供对lncRNA参与CRC的全面了解.
主要方法:
- 在CRC中对lncRNA功能的现有体外研究的审查和汇编.
- 对结直肠癌模型中 lncRNA 作用相关的体内数据的分析.
- 整合发现,绘制 lncRNA 与 CRC 中 JAK/STAT 路径之间的交叉对话.
主要成果:
- lncRNAs对JAK/STAT通路表现出多种影响,作为抑制剂或激活剂.
- 这些IncRNA介导的JAK/STAT信号调节会影响CRC的关键特征,如扩散,入侵,转移,亡,粘附和炎症.
- lncRNAs还在调节与CRC免疫疗法相关的免疫反应中发挥作用.
结论:
- lncRNAs是结直肠癌中JAK/STAT通路的关键调节者,影响瘤生物学的多个方面.
- 针对特定的 lncRNA 进行激活或抑制是阻碍CRC细胞增殖的有希望的策略.
- 对lncRNA-JAK/STAT相互作用的进一步研究对于开发新型诊断工具,治疗干预措施和针对CRC患者的个性化治疗策略至关重要.
相关概念视频
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


