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快速和缓慢的肌肉纤维转录组动态与终身耐力炼

Ulrika Raue¹, Gwenaelle Begue¹, Kiril Minchev¹

¹Human Performance Laboratory, Ball State University, Muncie, Indiana, United States.

Journal of applied physiology (Bethesda, Md. : 1985)

|December 14, 2023

概括

终身炼可以保持肌肉纤维功能和代谢健康. 快速肌肉纤维对运动的反应比慢纤维更强,在年轻人,终身运动者和不运动者中具有明显的分子特征.

科学领域:

肌肉生理学和分子生物学
运动科学运动科学
衰老的研究研究.

背景情况:

骨肌肉功能随着年龄的增长而下降.
终身炼对肌肉纤维转录组的影响尚不清楚.
了解快速和慢速肌肉纤维的年龄和运动相关的分子变化对于保持健康至关重要.

研究的目的:

在不同年龄和运动群体中调查快速和慢速肌肉纤维对抵抗运动的反应的转录组动态.
为了比较快速和慢速肌肉纤维之间的分子反应.
阐明终身运动对肌肉纤维适应的长期影响.

主要方法:

从终身炼者 (LLE),老年健康的非炼者 (OH) 和年轻的炼者 (YE) 的肌肉活检分析了抵抗运动前后的情况.
在孤立的快速和慢速肌肉纤维上进行了RNA测序 (RNA-seq).
评估了肌肉纤维的大小和收缩功能.

主要成果:

快速肌肉纤维在所有群体中都显示出比缓慢肌肉纤维对运动的转录反应更大.
年轻运动者的快纤维显示出增长和代谢特征,终身运动者的快纤维主要是代谢的,而老年非运动者的快纤维显示出应激反应.
只有终身炼者在缓慢的纤维中表现出显著的生物反应,与和脂质代谢有关.

结论:

终身运动显著影响肌肉纤维转录组动力学,促进快速和慢速纤维的代谢健康.
快速肌肉纤维对运动刺激的反应更强,年龄和运动史决定了特定的分子特征.
在一生中保持即使是适度的运动方案也可以为骨肌肉带来实质性的分子益处,提高随着年龄的增长的弹性和功能.

关键词:

衰老的衰老衰老的衰老运动就是炼身体.大师级运动员运动员这是骨肌肉的骨架肌肉.转录组 (transcriptome) 是一个转录组.

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