相关实验视频

Updated: Jul 8, 2025

A Rat Model of EcoHIV Brain Infection

A Rat Model of EcoHIV Brain Infection

Published on: January 21, 2021

鼠类肝炎E病毒 (Rocahepevirus ratti) 在感染艾滋病毒的人群中

María Casares-Jimenez¹, Antonio Rivero-Juarez^1,2, Pedro Lopez-Lopez^1,2

¹Infectious Diseases Unit, Reina Sofia University Hospital, Maimonides Instituto for Biomedical Research (IMIBIC), University of Cordoba (UCO), Cordoba, Spain.

Emerging microbes & infections

|December 14, 2023

概括

鼠类肝炎E病毒 (ratHEV) 正在西班牙出现,艾滋病毒感染者 (PLWH) 的抗体患病率为1.1%. 一个PLWH有可检测的老鼠HEVRNA,这表明在这个群体中存在潜在的动物感染威胁.

科学领域:

病毒学病毒学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

小鼠肝炎E病毒 (ratHEV) 是一种新兴的动物性病原体,可引起急性肝炎.
艾滋病毒感染者 (PLWH) 可能会面临HEV感染的更糟糕后果,这表明他们是ratHEV.HEV的高风险群体.

研究的目的:

确定大规模的西班牙PLWH队列中的鼠HEV感染和暴露的流行率.
评估这种脆弱群体中鼠HEV的潜在动物传染风险.

主要方法:

在西班牙进行的一项多中心研究,涉及西班牙艾滋病研究网络 (CoRIS) 的842名PLWH.
通过PCR检测鼠HEVRNA和使用点点分析检测抗鼠HEVIgG抗体.
对可检测到鼠HEV RNA的患者进行病毒性持续性和IgG血清转换的随访.

主要成果:

在9个人中发现了1.1% (95%CI:0.5%-2.1%) 的抗ratHEVIgG抗体的患病率.
一个个体 (0.1%的患病率;95%的CI:0.08%-0.7%) 对大鼠HEVRNA呈阳性,轻度ALT升高.
这个人在随访时表现出无法检测的老鼠HEV RNA和IgG血清转换.

结论:

鼠类肝炎E病毒在西班牙的地理分布.
RatHEV 构成了潜在的动物传染性威胁,特别是在感染艾滋病毒的人群中.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒乙型肝炎E病毒的感染.动物性疾病是动物性疾病.急性肝炎是一种急性肝炎.公共卫生公共卫生.鼠类肝炎 E 病毒

更多相关视频

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Prediction of HIV-1 Coreceptor Usage Tropism by Sequence Analysis using a Genotypic Approach

Prediction of HIV-1 Coreceptor Usage Tropism by Sequence Analysis using a Genotypic Approach

Published on: December 1, 2011

相关概念视频

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...