蝙蝠Eptesicus furinalis的丸回归和复发:形态生理变异和荷尔蒙信号通路
Larissa Mayumi Bueno1, Emília M Soares2, Juliana F Ferraz2
1Department of Zoology and Botany, UNESP-Universidade Estadual Paulista, São José do Rio Preto, Brazil.
Anatomical record (Hoboken, N.J. : 2007)
|December 14, 2023
概括
雄性蝙蝠经历丸回归和复发,由垂体,雄激素和雌激素激素控制. 这种荷尔蒙调节通过在生殖周期中影响塞尔托利和莱迪格细胞来影响精子生产.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 哺乳动物生理学哺乳动物生理学
背景情况:
- 雄性Eptesicus furinalis的年度生殖周期包括丸回归和暂时停止精子生产.
- 精子生成是一个由荷尔蒙信号调节的复杂过程,主要来自垂体腺和雄激素.
研究的目的:
- 通过四个繁殖阶段,研究治理Eptesicus furinalis丸的形态变异和荷尔蒙控制机制.
- 阐明垂体,雄激素和雌激素激素在调节丸回归和复发中的特定作用.
主要方法:
- 对18只成年雄性蝙蝠的丸进行了形态,形态测量和免疫组织化学分析.
- 样本被分为四个不同的阶段:活跃,回归,回归和复发.
主要成果:
- 在E. furinalis中,丸回归和复发是由垂体,雄激素和雌激素激素协调的.
- 激素调节涉及受体 (AR) 和Sertoli细胞中的卵泡刺激激素受体 (FSHR) 的交叉信号,以及莱迪格细胞中的黄素化激素受体 (LHR).
- 回归与塞尔托利细胞中AR表达的减少有关,抑制了精子的增殖和精子生成;复发涉及增加的LHR,AR和FSHR表达,重新激活激素生产和精子生成.
结论:
- 这项研究确定了控制丸季节性变化的关键荷尔蒙途径,在Eptesicus furinalis.
- 了解这些机制可以了解蝙蝠和其他哺乳动物的生殖内分泌学.
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