[酸性食道炎和酸性胃肠疾病]
Catrina Waldegg1, Thomas Greuter1,2,3
1Departement Innere Medizin, GZO Spital Wetzikon, Wetzikon.
Therapeutische Umschau. Revue therapeutique
|December 14, 2023
概括
乙酸性食管炎 (EoE) 和相关的乙酸性胃肠道疾病 (EGID) 越来越常见,导致食不适. 早期诊断和治疗带来了出色的结果,尽管在检测方面存在挑战.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 乙性食道炎 (EoE) 的发病率和流行率急剧上升,成为年轻人中食道障碍的主要原因.
- 非EoE的eosinophilic胃肠道疾病 (EGID) 较为罕见,但具有共同的病理生理重叠和类似疗法.
- 尽管布索尼德和杜皮卢马布等有效的治疗方法,但由于患者的补偿机制,EoE往往未被发现.
研究的目的:
- 总结目前对EoE和EGIDs的理解.
- 突出这些疾病的诊断方法和治疗选择.
- 强调早期检测和治疗对于有利的长期结果的重要性.
主要方法:
- 对EoE和EGIDs的当前文献的综述.
- 对诊断标准的分析,包括内镜活检.
- 评估可用的治疗方式,包括饮食改变,质子抑制剂 (PPI),局部皮质类固醇和单克隆抗体.
主要成果:
- EoE是通过食道活检诊断的,是年轻成年人中最常见的食道障碍的原因.
- 治疗反应很高,其中包括布德索尼德 (Jorveza) 和杜皮卢马布 (Dupixent) 的选择.
- EGIDs不太常见,有非特异性症状,但与EoE类似地治疗.
结论:
- 早期诊断和治疗EoE和EGID对于优秀的长期结果至关重要.
- 需要提高认识和改进诊断方法来应对日益增长的患病率.
- 尽管在检测方面存在挑战,但有效的疗法为患有这些eosinophilic胃肠道疾病的患者提供了积极的预后.
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