奎尔塞丁对阿米奥达龙的药理动力学和生物分布在老鼠的影响
E Ahmad1, M Jahangir, N I Bukhari
1Department of Chemistry, Government College University, Lahore, Pakistan. iwockd@gmail.com.
European review for medical and pharmacological sciences
|December 14, 2023
概括
奎尔塞丁 (QUE) 在大鼠中显著改变了阿米奥达龙 (AMD) 的药理动力学,增加了它的度. 这种药物相互作用需要人类研究和潜在的阿米奥达龙剂量调整.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物新陈代谢 药物新陈代谢
- 心血管研究研究心血管研究
背景情况:
- 阿米奥达龙 (AMD) 是一种具有狭窄治疗指数的关键抗失常药物.
- Quercetin (QUE) 是一种生物黄类物质,通过抑制P-糖蛋白和P450酶而影响药物的生物可用性.
- 同时使用Que和其他药物可能会改变它们的药理动力学特征.
研究的目的:
- 在大鼠模型中研究Quercetin (QUE) 和Amiodarone (AMD) 之间的药理动力相互作用.
- 评估 QUE 预治疗和同时使用对 AMD 的吸收,分布,新陈代谢和分泌 (ADME) 特性的影响.
主要方法:
- 进行了两项动物试验,以评估 QUE 对 AMD 药理动学的影响.
- 大鼠接受了14天的口服QUE预治疗,然后AMD,或同时服用QUE和AMD.
- 使用高性能液态染色学 (HPLC) 量化了AMD的血和肺组织度,并使用PK解决方案软件进行分析.
主要成果:
- QUE预治疗显著增加了AMD的峰值血度 (Cmax) 45.52%,曲线下的面积 (AUC0-∞) 13.70%.
- 同时服用Que和AMD导致Cmax增加12.90%,AUC0-∞增加7.80%.
- 两种QUE治疗方案都导致肺组织中AMD水平增加,AMD清除率降低.
结论:
- 在大鼠中,Que和AMD之间存在显著的药物相互作用.
- 这些发现表明需要进行临床研究来评估人类的这种相互作用.
- 在患者同时服用含有QUE的产品时,可能需要对AMD进行潜在的剂量调整,特别是那些有治疗前史的患者.
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