肠道微生物群,SCFA和猪脂肪酸组成之间的相互关系
Cristina Sebastià1,2, Josep M Folch1,2, Maria Ballester3
1Plant and Animal Genomics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB Consortium, Bellaterra, Spain.
mSystems
|December 14, 2023
概括
肠道细菌影响猪的新陈代谢. 像Prevotella和Akkermansia这样的特定微生物与短链脂肪酸相关,而Rikenellaceae RC9肠道组与肌肉和脂肪中的脂质配置相关.
科学领域:
- 微生物学 微生物学
- 动物科学动物科学
- 营养生物化学 营养生物化学
背景情况:
- 肠道微生物群在宿主新陈代谢中起着至关重要的作用,包括将难以消化的化合物发酵成短链脂肪酸 (SCFA).
- SCFA可以被宿主转化并积聚在组织中,可能影响肉质特征.
- 了解肠道微生物与宿主脂质代谢之间的相互作用,对于优化动物生产和健康至关重要.
研究的目的:
- 调查肠道微生物组成和直肠内容中的SCFA概况之间的相关性.
- 探索直肠微生物和SCFA概况与猪背脂和肌肉中的脂肪酸成分之间的潜在联系.
- 确定特定的细菌属,可以作为SCFA和猪脂质代谢的生物标志物.
主要方法:
- 对Duroc × 伊比利亚杂交猪种群的分析.
- 细菌和古物种种数量和脂肪酸概况 (直肠含量,背部脂肪,肌肉) 之间的相关性分析.
- 确定特定微生物种群与SCFA和脂质代谢产物之间的显著关联.
主要成果:
- 在各种细菌/古生物属和脂肪酸特征之间观察到显著的相关性.
- 普雷沃特拉 (Prevotella) spp. spp. 是一种植物. 丰富度与直肠含量中的n-黄油酸具有积极的关联,与酸具有负面的关联.
- 艾克尔曼西亚 (Akkermansia) spp. spp. 的一个地方. 显示了与n-黄油酸的反向关联和与酸的积极关联.
- 瑞肯氏家族的RC9肠群属与肌肉中的棕酸正相关,与肌肉中的脊脂中的牛油酸和肌肉中的油酸负相关.
结论:
- 普雷沃特拉 (Prevotella) spp. spp. 是一种植物. 和阿克克曼西亚spp. 可以作为猪中酸和n-黄油酸的潜在生物标志物.
- 里肯氏菌 (Rikenellaceae) RC9肠道组可能与脂质代谢有关,这表明肠道微生物群在修改背脂和肌肉脂肪酸组成方面发挥了间接作用.
- 这些发现突显了肠道微生物群和宿主脂质代谢之间的复杂关系,为通过微生物干预提供了潜在操纵的见解.
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