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Updated: Jun 11, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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合成和抗增殖评估d-Glucuronamide基核化物和 (Triazolyl) 甲基胺相关的伪二糖核化物

Tânia Moreira1, Domingos M Manuel1, Joana Rosa1

  • 1Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, 5° Piso, Campo Grande, 1749-016, Lisboa, Portugal.

ChemMedChem
|December 14, 2023
PubMed
概括

新型含有葡萄糖胺胺的核酸被合成并对抗癌活性进行评估. 一些十二基化纯氨酸核酸对乳腺癌 (MCF-7) 和慢性髓性白血病 (K562) 细胞产生显著的抗增殖作用,通过诱导亡作用.

关键词:
在N-glycosylation的过程中.它们具有抗增殖活动的抗增殖活性.这是一个循环加法循环.d-glucuronamide 的使用方法核酸类型的类似物.

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