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以废水为基础的监测作为公共卫生行动的工具:SARS-CoV-2及以后

Michael D Parkins^1,2,3, Bonita E Lee⁴, Nicole Acosta²

¹Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

Clinical microbiology reviews

|December 14, 2023

概括

在COVID-19期间,基于废水的监测 (WBS) 迅速发展,成为SARS-CoV-2传播的主要指标. 本次审查涵盖了WBS的创新及其扩展到其他传染病.

科学领域:

环境科学环境科学
公共卫生公共卫生
分子生物学分子生物学

背景情况:

在COVID-19大流行期间,基于废水的监测 (WBS) 迅速发展.
废水中的SARS-CoV-2RNA水平与临床疾病相关,并作为主要指标.
创新使得可从不同地点收集废水,并进行高效的RNA分析.

研究的目的:

提供对SARS-CoV-2废水监测的最新审查.
详细介绍 WBS 检测传染病方法的进展.
突出WBS作为公共卫生工具的潜力.

主要方法:

审查废水收集和SARS-CoV-2样本处理方面的全球创新.
适应分子和基因组工具以识别和量化废水中的SARS-CoV-2RNA和变体.
开发数据共享平台,以实时进行公共卫生决策.

主要成果:

世界疾病统计局 (WBS) 展示了变革性的潜力,提供了成本效益高,近乎实时的疾病流行率数据.
由于快速的创新,目前的SARS-CoV-2 WBS文献存在显著的异质性.
目前,WBS正在扩展到监测其他传染病点.

结论:

世界卫生健康系统是监测人口健康的强大,客观和包容性工具.
需要对WBS方法进行标准化,以应对当前的异质性.
将WBS扩展到其他病原体对公共卫生监测具有重大前景.

关键词:

在 COVID-19 疫情中,抗微生物耐药性抗微生物耐药性脊髓灰质炎:脊髓灰质炎是一种疾病.污水污水处理污水污水处理废水是废水,废水就是废水.基于废水的流行病学.

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