在断奶期间消耗霍乱毒素抑制了小鼠的化学诱导癌症发生
Hara Afaloniati1, Georgios Aindelis2, Katerina Spyridopoulou2
1Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
International journal of cancer
|December 14, 2023
概括
在小鼠中,早期暴露于霍乱毒素 (CT) 减少了瘤的发展和改善了生存率. 这表明CT塑造了免疫力和肠道微生物组,为终身癌症保护提供了保护.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 胃肠道细菌影响局部和全身免疫力,影响癌症的发展.
- 围产期细菌暴露可能建立终身免疫系统能力.
- 霍乱毒素 (CT) 是一种来自Vibrio cholerae的外毒素,研究了其免疫调节作用.
研究的目的:
- 为了确定CT在生命早期的口服是否能保护远端上皮质瘤的发展.
- 研究CT对局部和全身免疫以及肠道微生物群的影响.
- 了解CT可以预防癌症的机制.
主要方法:
- 新生小鼠被口服治疗,使用低剂量,非致病性CT.
- 随后,小鼠接受了致癌物7,12-二甲基桑烯 (DMBA) 的挑战.
- 分析了瘤发生率,多重性,存活率,亡,免疫细胞概况,基因表达和肠道微生物群组成.
主要成果:
- 对CT的施用抑制了各种癌症类型的整体瘤发病率和多重性,提高了生存率.
- CT并没有防止前性病变,但阻碍了它们向瘤的进展.
- CT增加了易患癌症的组织中的亡,并改变了与癌症相关的基因表达.
- 长期影响包括全身中性粒细胞减少和肠道细菌菌群组成的显著改变 (例如,从Clostridia转变为Bacilli).
结论:
- 早期的CT消费塑造了宿主免疫力,微生物组和基因表达特征.
- 这些修改有助于预防癌症的发展.
- 对CT的管理代表了终身癌症化学预防的潜在策略.
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