通过使用固体分散和泡分解技术,提高溶解速度和口服生物可用性 难溶药物florfenicol
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Updated: Jul 8, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Chao Li1, Nanxin Li1, Xingyu Chen1
1Department of Pharmacy, College of Vet Medicine, Sichuan Agricultural University, Chengdu, China.
装有弗洛芬尼科尔固体分散剂 (FF-SD-FDTs) 的快速分解片被开发用于增强这种兽医抗生素的口服生物可用性. 这些新的药片显著改善了Florfenicol的性能.
科学领域:
- 兽医药理学 兽医药理学
- 药物输送系统 药物输送系统
- 药品制造 药品制造 药品制造
背景情况:
- 佛罗芬尼科尔 (FF) 是一种重要的兽医抗生素,其溶解性和生物可用性有限.
- 药物的溶解性差,阻碍了动物治疗中有效的治疗结果.
研究的目的:
- 为了提高Florfenicol的溶解率和口服生物可用性.
- 为了探索快速分解药片 (FDTs) 的有效性,这些药片配备了Florfenicol-loaded固体分散剂 (FF-SDs).
主要方法:
- 使用溶剂蒸发方法制备了佛罗芬尼科尔固体分散剂 (FF-SDs).
- 快速分解片 (FF-SD-FDTs) 是通过直接压缩制造的.
- 进行了体外溶解和体内药理动力学研究.
主要成果:
- FF-SD-FDTs满足了中国兽医药典对药片特性的规格.
- 与传统药片相比,体外研究表明药物溶解和分散显著改善.
- 狗的药理动力学研究显示,FF-SD-FDTs的AUC0-∞和Cmax比传统药片增加了1.38倍.
结论:
- 成功开发了具有卓越分解和溶解配置的FF-SD-FDT.
- 这种新型配方大大提高了Florfenicol的口服生物可用性.
- 这种方法提供了一个有前途的策略,以提高像佛罗芬尼科尔 (Florfenicol) 这样的溶性较差药物在兽医中的临床应用.
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