通过多omics解开代谢综合征的表型变异
Lamessa Dube Amente1,2,3, Natalie T Mills4, Thuc Duy Le5
1Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia. lamessa.amente@mymail.unisa.edu.au.
Human genetics
|December 14, 2023
概括
这项研究揭示了基因组,转录基因组,代谢基因组和暴露基因组如何共同影响代谢综合征 (MetS) 和相关因素. 了解这些多omics相互作用对于解释心脏代谢健康的表型变异至关重要.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 代谢研究研究 代谢研究
- 生物信息学是一种生物信息学.
背景情况:
- 心脏代谢风险因素往往由于复杂的多omics影响而聚集在一起.
- 了解个人和组合的奥米克层如何塑造表型变异是必不可少的.
研究的目的:
- 使用多omics数据,对代谢综合征 (MetS) 和其组成部分 (葡萄糖,甘油三,HDL-C,血压) 的表型变异进行分割.
- 研究基因组,转录基因组,代谢基因组和暴露基因组对心脏代谢特征的单独和综合影响,包括相互作用和共变性.
主要方法:
- 在英国生物库队列 (n=62,822) 上使用了具有限制最大概率 (REML) 的线性混合模型.
- 分析了个别的omics层,然后进行双向和联合建模,以解释omics共变性和相互作用.
- 使用双变REML的omics效应和表型之间的估计相关性.
主要成果:
- 代谢组解释了最大比例的MetS变异 (14.34%),其次是基因组 (9.47%),转录组 (4.24%) 和暴露组 (3.77%).
- 个人奥米克解释了特定特征的不同百分比变异,例如,基因组高达HDL-C的25.35%,代谢组高达TG的35.75%.
- 在奥米克层之间和跨表型之间检测到显著的相关性和相互作用效应.
结论:
- 多omics数据,包括基因组,转录组,代谢组和暴露组,对MetS和相关特征的表型变异作出了重大贡献.
- 欧米克层之间的相互作用和协差对于全面了解心脏代谢健康至关重要.
- 这项研究突显了综合多组学分析在剖析复杂疾病表型方面的力量.
相关概念视频
Genomics
36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.4K
Polygenic Traits
65.9K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.9K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Variability: Analysis
143
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
The range is a simple measure of variability, indicating the difference between the highest and...
143
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Human Genetics
583
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
583


