产妇和新生儿的代谢变化与分娩时尿路多环芳化合物代谢物度相关:一种非向的方法
Jagadeesh Puvvula1, Kathrine E Manz2, Joseph M Braun3
1Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jagadeesh.Puvvula@pennmedicine.upenn.edu.
Metabolomics : Official journal of the Metabolomic Society
|December 14, 2023
概括
产前暴露于多环芳 (PAHs) 与改变母亲和新生儿的代谢概况有关. 这项研究发现,母亲的PAH水平与母亲和婴儿的代谢途径之间存在关联.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 生殖健康 生殖健康
背景情况:
- 产前暴露于多环芳 (PAHs) 是已知的健康不良结果的风险因素.
- 了解孕产妇暴露于PAH对孕产妇和新生儿代谢的影响,对于识别潜在的健康风险至关重要.
研究的目的:
- 为了研究母体尿中PAH代谢物度与母体/新生儿血清代谢概况之间的关联.
- 为了确定受产前PAH暴露影响的特定代谢途径.
主要方法:
- 一项涉及俄俄州辛辛那提75名孕妇的横截面研究.
- 在母亲尿液中定量8个单氧化PAH代谢物.
- 非定位的高分辨率质谱分析母体和新生儿血清代谢组.
- 线性回归和Benjaminini-Hochberg校正用于统计分析.
- 功能分析以确定受影响的生物途径.
主要成果:
- 全代谢相关性研究 (MWAS) 显示,新生儿和母体代谢特征的1-2%与母体PAH代谢产物有关.
- 单个PAH代谢物与代谢途径的改变有关,包括维生素,氨基酸,脂质,碳水化合物和异生菌.
- 在母体和新生儿血清样本中都观察到显著的关联.
结论:
- 在怀孕后期,母亲尿液中PAH度与母亲和新生儿的不同代谢概况有关.
- 这些发现突显了代谢组在调解PAH暴露和不良妊娠结果之间的关系方面的潜在作用.
- 需要进一步的研究来探索这些调解效应及其临床影响.
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