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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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相关实验视频

Updated: Jul 8, 2025

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research
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ICBcomb:一个针对免疫检查点阻断组合疗法的综合表达数据库.

Yun Xia1, Yan Gao1, Ming-Yu Liu1

  • 1Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Briefings in bioinformatics
|December 14, 2023
PubMed
概括

一个新的数据库ICBcomb分析了免疫检查点阻塞 (ICB) 组合疗法的基因表达. 本资源有助于理解治疗机制,并发现用于癌症免疫治疗的新型组合药物.

关键词:
生物信息学是一种生物信息学.癌症 癌症 癌症 癌症 癌症组合疗法治疗组合治疗.我们的数据库数据库数据库数据库.免疫疗法 免疫疗法瘤免疫学 瘤免疫学

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科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.

背景情况:

  • 免疫检查点阻塞 (ICB) 是一种关键的癌症免疫疗法,但有限的反应率需要组合疗法.
  • 对于ICB组合疗法的基因表达模式尚不清楚,这阻碍了药物发现和机制性见解.

研究的目的:

  • 构建ICBcomb,用于ICB组合疗法的基因表达特征的综合数据库.
  • 为了促进基因表达,丰富和免疫细胞透在ICB组合治疗的分析.

主要方法:

  • 从ICB组合治疗试验中分析人类和小鼠表达数据.
  • 开发一个用户友好的网络界面,包含数据集/疾病,基因,基因组和免疫细胞分析的模块.
  • 用ICB,其他药物或组合治疗组之间的表达数据的比较.

主要成果:

  • ICBcomb整合了29种癌症类型和52种药物的1399个样本.
  • 数据库提供了浏览表达式,丰富和比较结果的工具.
  • 功能模块可以对基因表达,基因组和免疫细胞透进行详细的分析.

结论:

  • ICBcomb是ICB组合疗法中基因表达特征的第一个数据库资源.
  • 该数据库可以阐明有效组合策略的机制,并指导新组合药物的发现.