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瘤特异性混合纳米粒子用于乳腺癌治疗

E Kilicay¹, E Erdal², P Elci³

¹Vocational High School of Eldivan Health Care Services, Karatekin University, Cankiri, Turkey.

Journal of microencapsulation

|December 14, 2023

概括

含有咖啡酸和叶酸的酸化聚3-基酸) 纳米颗粒对乳腺癌治疗有希望,证明了有效的封装和持续的药物释放.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

聚3-基酸盐 (PHB) 是一种生物降解的聚合物,具有药物输送潜力.
咖啡酸 (Caff) 和叶酸 (FA) 具有抗癌性质.
开发有效的纳米粒子 (NP) 传递系统对于癌症治疗至关重要.

研究的目的:

开发酸 (SA) 化PHB纳米颗粒 (NP) 用于增强乳腺癌治疗.
在这些NP中封装咖啡酸 (Caff) 和叶酸 (FA).
评估开发的NP的物理化学特性,稳定性,药物释放和抗癌疗效.

主要方法:

使用溶剂蒸发方法制备纳米粒子.
描述包括FTIR,DSC,SEM和动态光散射 (DLS) 以大小,多分散度指数 (PDI) 和泽塔潜力 (ZP) 来进行.
在试验室释放,稳定性,细胞毒性 (MTT试验),细胞死亡和细胞内化 (光素,共聚焦显微镜) 被评估.

主要成果:

这些NP的平均直径为172±7nm,ZP为-29±0.38mV.
5%和10%的Caff NP的捕获效率分别为79 ± 0.23%和70 ± 0.42%.
NPs在30天内表现出良好的稳定性,持续释放25天,FA-5Caff NPs在MCF-7细胞上显示了37 ± 0.3%的活力.

结论:

用SA合的PHBNP有效地封装了Caff和FA.
开发的NP表现出有利的物理化学特性,稳定性和持续的药物释放.
FA-Caff NPs代表了乳腺癌治疗的有前途的载体系统.

关键词:

在MCF-7中使用.盐酸盐酸是什么盐酸盐酸是什么咖啡酸是一种咖啡酸.叶酸是叶酸的一种.聚基酸) 是一种聚基酸 (聚基酸) 化合物.

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