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Updated: Jul 8, 2025

Preparation and Culture of Rat Lens Epithelial Explants for Studying Terminal Differentiation
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Preparation and Culture of Rat Lens Epithelial Explants for Studying Terminal Differentiation

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对于镜片上皮细胞增殖和镜片纤维成熟在小鼠镜片发育中的JAM-C很重要

Qihang Sun1, Jiani Li1, Jingyu Ma1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Investigative ophthalmology & visual science
|December 14, 2023
PubMed
概括

结合粘附分子C (JAM-C) 缺乏,通过减少细胞增殖和破坏纤维成熟,损害了小鼠透镜的发育. 这可能涉及FOXE3下调和改变连接素分布,影响先天性白内障机制.

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Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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