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神经元树突中的 lysosomal 密度降低在亨廷顿病中介于突触可塑性的缺陷

Jia-Hui Chen1, Na Xu2, Lei Qi3

  • 1Department of Neurology and Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China; CAS Key Laboratory of Brain Function and Disease, MOE Key Laboratory for Membrane-less Organelles & Cellular Dynamics, Neurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230027, China.

Cell reports
|December 14, 2023
PubMed
概括

亨廷顿氏病 (HD) 与大脑树突中的 lysosome 密度降低有关,影响学习和记忆. 在树突中恢复 lysosome 定位可以在 HD 鼠标模型中拯救这些认知缺陷.

关键词:
在CAG-140小鼠身上.CP: 细胞生物学 细胞生物学科普:神经科学:神经科学是一门学科.在海马体内,海马体由光引起的二度化.长期增强潜力 长期增强潜力lysosome 溶解酶体是如何形成的在光学遗传学方面,光学遗传学是指光学遗传学.

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