局部加巴丁溶液用于治疗口腔炎综合征:一项回顾性研究
Amanda Gramacy1, Alessandro Villa1,2
1Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, United States of America.
PloS one
|December 14, 2023
概括
局部加巴丁溶液有效地减少了口腔炎综合征 (BMS) 疼痛,平均减少了两分. 这种治疗被患者容忍得很好,显示出BMS管理的希望.
科学领域:
- 口腔医学是指口腔医学.
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 燃烧口腔综合征 (BMS) 是一种影响口腔粘膜的慢性疼痛状况.
- 目前的BMS管理选项的有效性和耐受性有限.
- 局部 gabapentin 提供了一个潜在的局部治疗方法.
研究的目的:
- 评估局部 gabapentin 溶液 (250 毫克/毫升) 对 BMS 的有效性和安全性.
- 为了评估疼痛减轻使用10点数值评分表 (NRS).
- 为了确定与局部 gabapentin 相关的任何不良药物反应 (ADR).
主要方法:
- 对19名用 gabapentin 250 mg/mL 溶液 (swish 和 spit) 治疗的 BMS 患者的回顾性图表审查.
- 收集关于燃烧分数 (NRS) 和ADRs变化的数据.
- 威尔科克森签名等级测试用于疼痛得分的统计分析.
主要成果:
- 观察到燃烧得分 (NRS) 中位数下降2分 (p < 0.01).
- 15.8%的患者报告药物不良反应.
- 随访时间中位数为86天.
结论:
- 局部加巴丁 (250毫克/毫升) 在BMS管理中似乎有效且耐受良好.
- 这项研究强调了局部加巴丁治疗的潜力.
- 建议进行进一步的随机前性研究来证实这些发现.
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