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莫莫迪卡巴尔萨米纳 (Momordica balsamina) 在饮食诱导的糖尿病前老鼠模型中改善了葡萄糖处理
Bongiwe Khumalo1, Angezwa Siboto1, Akinjide Moses Akinnuga1,2
1Department of Physiology, School of Laboratory Medicine and Medical Science, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa.
PloS one
|December 14, 2023
概括
莫莫迪卡巴尔萨米纳 (MB) 通过改善葡萄糖平衡,减少体重,提高胰岛素敏感度,有效地管理糖尿病前期. 这种草药治疗有望防止2型糖尿病的进展,即使没有改变生活方式.
科学领域:
- 代谢障碍和内分泌学
- 药理学和草药医学 药理学和草药医学
背景情况:
- 长时间的高能量饮食有助于糖尿病前期,这是2型糖尿病 (T2DM) 的前体.
- 目前的干预措施结合了药理治疗和饮食改变,但患者对饮食建议的遵守往往很差.
- 莫莫迪卡香 (MB) 在1型糖尿病模型中表现出抗糖尿病作用,但其在糖尿病前期管理中的作用尚未确立.
研究的目的:
- 评估Momordica balsamina (MB) 在饮食诱导的糖尿病前期大鼠模型中控制葡萄糖平衡的疗效.
- 评估MB与并发饮食干预或不同时对糖尿病前老鼠的影响.
主要方法:
- 在男性斯普雷格·道利大鼠中诱导糖尿病前期,使用高脂肪,高碳水化合物 (HFHC) 饮食20周.
- 糖尿病前的老鼠每三天口服MB (250毫克/千克),持续12周,随着或没有标准的饮食干预.
- 评估结果包括热量摄入量,体重,血格林,糖化血红蛋白 (HbA1c),胰岛素敏感性标志物 (GLUT 4,糖原合成酶).
主要成果:
- 服用MB,有或没有饮食干预,显著改善了葡萄糖平衡.
- 与对照组相比,接受治疗的老鼠表现出较低的热量摄入量,体重,血格林和糖化血红蛋白.
- MB增强了胰岛素敏感性,由增加的葡萄糖载体4 (GLUT4) 和糖原合成酶表达体现出来.
结论:
- 莫莫迪卡巴尔萨米纳 (Momordica balsamina) 在治疗糖尿病前期和预防发展为2型糖尿病中具有显著的潜力.
- MB有效地恢复葡萄糖平衡,改善新陈代谢参数,即使没有伴随的饮食或生活方式改变.
- 这些发现支持使用MB作为治疗前糖尿病管理的治疗剂.
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