质子抑制剂对帕金森病的潜在风险:全国性嵌套病例控制研究
Ji Taek Hong1, Hye-Kyung Jung1, Kwang Jae Lee2
1Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
PloS one
|December 14, 2023
概括
质子抑制剂 (PPI) 的使用可能会增加帕金森氏症.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 质子抑制剂 (PPI) 是广泛使用的药物.
- 目前正在调查PPI使用与神经退行性疾病 (包括帕金森病) 之间的潜在联系.
- PPI与PD风险之间的关联仍然不清楚.
研究的目的:
- 调查使用质子抑制剂 (PPI) 与患帕金森病 (PD) 的风险之间的关联.
- 探索潜在的剂量反应关系以及影响这种关联的因素.
主要方法:
- 使用韩国国家医疗保险服务数据库 (2010-2019) 进行的大规模回顾性队列研究.
- 31,326名新诊断的PD患者与125,304名对照进行了匹配.
- 使用条件后勤回归分析来评估相关性,并使用滞后期来缓解原发病偏差.
主要成果:
- 在1年的滞后期后,使用PPI显著与PD风险增加有关 (调整后OR,1.10;95% CI,1.07-1.13).
- 在累积PPI定义的每日剂量和PD发展之间观察到显著的积极剂量反应关系 (P<0.001).
- 这种关联在2年和3年滞后期保持一致,不受性别的影响.
结论:
- 这项研究表明,使用质子抑制剂与帕金森病风险增加之间存在显著的关联.
- 一个剂量-反应关系进一步支持这一发现.
- 需要进一步的长期后续研究来证实这些结果并阐明潜在的机制.
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