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在缺血性中风患者中,脏测量和认知表现之间的关联

Chunyan Zhang¹, Guofang Xue¹, Yanjuan Hou²

¹Department of Neurology, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.

|December 14, 2023

概括

降低估计的淋巴膜过率 (eGFR) 与中风患者的认知功能较差有关. 专发病没有与中风后的认知表现有显著的关联.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
神经学神经学
老年病的医生老年病的医生

背景情况:

慢性病 (CKD) 会增加中风风险,并可能导致认知障碍.
由于有相互矛盾的证据,降低功能 (eGFR) 和与中风后认知衰退的白尿之间的关系需要进一步澄清.

研究的目的:

为了研究低估计的淋巴细胞过率 (eGFR) 和白色素尿与缺血性中风后患者的认知表现的独立和联合关联.

主要方法:

一项对608名急性缺血性中风患者的回顾性研究.
在出院后一个月使用MMSE和MoCA评估认知功能.
通过回归分析分析了eGFR和尿白蛋白-肌素比率 (UACR),并对多个混因素进行了调整.

主要成果:

较低的eGFR独立地与MMSE和MoCA的显著较差表现相关.
专尿 (UACR) 与认知测试成绩没有显著的相关性.
大多数患者的EGFR≥60毫升/分钟/1.73米2 (95%) 和UACR<300毫克/g (95%) .

结论:

降低EGFR,而不是白蛋白尿,与缺血性中风后的认知表现下降有关.
eGFR下降可能作为中风后认知障碍的指标.
建议在中风患者中常规监测功能障碍,以早期发现认知问题.

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