Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Making the Invisible Wounds of War Visible.

Military medicine·2026

Same author

γ-radiation reduces phosphorylated-tau in rhesus macaque brains: potential implications for Alzheimer's disease and other tauopathies.

Alzheimer's research & therapy·2026

Same author

Non-Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions.

Brain pathology (Zurich, Switzerland)·2026

Same author

Long-term molecular effects of <sup>16</sup>O-ion exposure in rat brain and implications for space radiation risk.

NPJ microgravity·2026

Same author

Neuropathological and Behavioral Effects of Mild Traumatic Brain Injury at High Altitude.

Journal of neurotrauma·2026

Same author

γ-Radiation Reduces phosphorylated-Tau in RhesusMacaque Brains: Potential Implications forAlzheimer's Disease and other Tauopathies.

Research square·2026

Search research articles

相关实验视频

Updated: Jul 8, 2025

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

在重复的爆炸驱动爆炸后,海马体的蛋白质变化.

Diego Iacono^1,2,3,4,5,6, Kathleen Hatch³, Erin K Murphy³

¹DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.

Journal of proteome research

|December 14, 2023

概括

反复暴露于爆炸会导致大鼠海马中的分子变化,即使没有行为症状. 这些发现表明,与特定蛋白质变化相关的无症状爆发诱导分子变化状态 (ABIMAS).

关键词:

无症状的爆炸引起的分子改变状态.冲击波主要影响冲击波主要影响爆炸式驱动的爆炸.在海马体内,海马体与膜相关的酸酶逆转3 (MAGI3)反复暴露于爆炸的重复暴露.双重质量标签蛋白质组学蛋白质组学创伤性脑损伤是一种创伤性脑损伤.

更多相关视频

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

相关实验视频

Last Updated: Jul 8, 2025

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

科学领域:

神经科学是一个神经科学.
蛋白质组学是指蛋白质组学.
创伤性脑损伤创伤性脑损伤

背景情况:

重复的爆炸性创伤性脑损伤 (爆炸性创伤性脑损伤) 与服务人员的神经和精神问题有关.
爆炸波引起的大脑损伤的确切机制和后果仍然不清楚.
之前的研究指出,在暴露于爆炸后,大鼠大脑的分子变化.

研究的目的:

用质谱测量来比较经过双重爆炸和假条件的老鼠海马的蛋白质组概况.
在没有明显的基因病理或行为改变的情况下,识别与重复的爆炸暴露相关的特定蛋白质变化.

主要方法:

采用基于质量标签的双重质量谱法 (TMT-MS) 进行无偏的蛋白质组定型.
在双爆和假老鼠群体之间分析了海马中的蛋白质丰度差异.
确认了特定的蛋白质变化,如MAGI3,使用西式涂抹.

主要成果:

与假老鼠相比,在双爆老鼠的海马体内发现了蛋白质表达的显著差异.
在TMT-MS中,发现了136种上调和94种下调的蛋白质.
观察到新的变化,包括增加的MAGI3蛋白水平,此前在爆发研究中没有报告过.

结论:

蛋白质组数据支持无症状的爆炸诱导分子改变状态 (ABIMAS) 的存在.
特定的海马蛋白质变化发生,即使在反复暴露于爆炸后没有明显的行为或组织病理损伤.
这些发现凸显了爆炸TBI后微妙分子变化的潜力.