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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

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Published on: January 7, 2019

基于微阵列的CD38探头查多发性骨髓瘤成像

Xuejie Li^1,2, Yuanzhuo Wang², Qi Yang³

¹Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, China.

Molecular pharmaceutics

|December 14, 2023

概括

此摘要是机器生成的。

这项研究开发了一种高通量微阵列芯片平台,用于选多发性骨髓瘤 (MM) 的关键目标CD38的质探针. 新的探测器在体内证明了特定的瘤向,为MM诊断和成像提供了一个有前途的工具.

关键词:

CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 在活体中成像成像基于微芯片的选多发性骨髓瘤 (MM) 是一种向的向的向.

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科学领域:

生物医学工程生物医学工程
分子成像分子成像技术
在瘤学瘤学.

背景情况:

CD38表达对于多发性骨髓瘤 (MM) 治疗至关重要,有助于检测病变和预测治疗疗效.
准确的MM诊断需要先进的分子探针用于向成像和治疗,需要高通量查平台.

研究的目的:

调查基于微阵列芯片的战略,用于针对CD38.8的化物探针的高通量选.
开发用于多式成像和CD38阳性多发性骨髓瘤的潜在治疗应用的新探针.

主要方法:

一个微阵列芯片平台被用来选一个类库的CD38特定的结合剂.
鉴定的 (CA-1,CA-2) 的特征是特异性和亲和力 (K_D 10-7 M).
类探针被标记为绿色 (ICG) 和Ga-DOTA用于瘤携带小鼠的多式成像.

主要成果:

成功识别了两个新的CD38向,CA-1和CA-2.
分子和细胞测试证实了开发的探针的特异性和高亲和力.
小动物光和正子发射断层扫描 (PET) 图像显示,CD38阳性拉莫斯瘤中的探针具有特定的丰富性.

结论:

基于微芯片的查方法对于开发有针对性的分子探针是有效的.
已识别的探针显示出作为CD38阳性多发性髓瘤的成像剂的显著潜力.
这一战略为推进多发性骨髓瘤的诊断工具提供了一个有希望的途径.