冠状病毒疾病2019 (COVID-19) 和静脉血栓栓塞在怀孕和产后期间
Ann M Bruno1, Joshua J Horns, Torri D Metz
1University of Utah Health, Salt Lake City, and Intermountain Healthcare, Murray, Utah.
Obstetrics and gynecology
|December 14, 2023
概括
患有严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染的孕妇面临更高的静脉血栓塞栓症 (VTE) 风险. 这项研究强调了在这种高风险产科患者群体中考虑血栓预防的必要性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与血栓事件的风险增加有关.
- 目前的指导方针建议对患有SARS-CoV-2的未怀孕住院患者进行血栓预防.
- 关于SARS-CoV-2的孕妇和产后患者的静脉血栓塞栓症 (VTE) 的国家数据有限.
研究的目的:
- 为了评估SARS-CoV-2感染与孕妇和产后患者的VTE风险之间的关联.
- 为了比较怀孕/产后患者与没有SARS-CoV-2感染的VTE发病率.
主要方法:
- 使用MarketScan商业保险数据库 (2016-2020) 进行的回顾性队列研究.
- 纳入标准:年龄在18岁以上的个体,在怀孕>20周时分娩.
- 对811,008例分娩的分析,以评估与怀孕或产后的SARS-CoV-2感染相关的VTE发生情况.
主要成果:
- 在怀孕期间或产后6周内感染SARS-CoV-2与VTE风险显著增加有关 (1.0%与0.5%相比).
- 在SARS-CoV-2感染个体中,VTE的调整后危险比为2.62 (95%CI为1.60-4.29).
结论:
- 怀孕期间和产后期间的SARS-CoV-2感染与VTE的风险大幅增加有关.
- 研究结果表明,应进一步考虑对被诊断患有SARS-CoV-2感染的产科患者进行血栓预防治疗.
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