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粘膜和全身抗原特异性抗体反应与对非人类灵长类动物活性结核病的保护相关

Elise Ishida¹, Devin T Corrigan², Tingting Chen²

¹Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.

|December 14, 2023

概括

预先存在的抗体,特别是针对特定Mycobacterium tuberculosis (Mtb) 甘氨基基基基因的IgA,可以预防结核病 (TB). 早期对Mtb蛋白的IgG反应也似乎对结核病控制有好处.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
结核病研究结核病研究

背景情况:

抗体显示出保护活动性结核病 (TB) 的潜力.
关于保护性抗原的知识有限,特别是在呼吸道.
研究目标:确定与潜在结核病感染 (LTBI) 相关的抗原特异性抗体反应与活性结核病.

研究的目的:

确定抗原特异性气道和全身免疫球蛋白同型反应.
将这些反应与Mycobacterium tuberculosis (Mtb) 感染 (LTBI与TB) 的结果相关联.

主要方法:

对57只感染Mtb的Cynomolgus进行了病例控制研究.
评估气道和全身IgG,IgA和IgM.
在抗原无偏见的方法中使用了Mtb甘氨酸和蛋白质组范围的微阵列.

主要成果:

在LTBI中,感染前IgA对特定的阿拉比诺南 (AM) 动机 (气道和血) 的IgA较高.
在LTBI上,早期感染后血IgG对MTB32A的水平较高 (Rv0125).
随着时间的推移,在LTBI中观察到对某些蛋白质的呼吸道IgG反应的增加.

结论:

以前存在的粘膜和全身IgA到Mtb甘氨酸基因可能具有保护作用.
表明先前接触非结核性菌根菌可能会提供保护.
对Mtb蛋白的早期IgG反应可能提供额外的保护机制,为结核病疫苗的开发提供信息.

关键词:

阿拉伯人阿拉伯人免疫球蛋白A是一种免疫球蛋白.免疫球蛋白是一种免疫球蛋白.利波阿比诺比诺南南是什么意思聚糖类是一种多糖类.结核病是一种疾病.

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