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大肠杆菌序列131型的肠道微生物组预测因素殖民和损失

Daniel E Park¹, Maliha Aziz¹, Benjamin J Koch²

¹Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA.

|December 14, 2023

概括

特定的肠道细菌,如Collinsella和Alistipes,与携带和丧失多抗药性大肠杆菌ST131-H30R有关. 这些发现可能会为控制这种病原体的基于微生物组的策略提供信息.

科学领域:

微生物学微生物学
肠道微生物组研究研究
传染性疾病传染性疾病

背景情况:

大肠杆菌序列类型131 (ST131),特别是耐诺 H30R 类 (ST131-H30R),是一个重要的全球多药耐药病原体.
肠道微生物组在ST131-H30R肠道载体中的作用在很大程度上仍未被定义.

研究的目的:

调查肠道微生物组组成和ST131-H30R的肠道载体之间的联系.
确定与ST131-H30R携带,持久性和损失相关的特定细菌种群.

主要方法:

从2014年到2018年,对退伍军人和家庭成员进行了纵向便拭子监测.
用16S rRNA qPCR和测序分析了肠道微生物组的组成.
使用随机森林模型和混合效应物流回归来评估微生物组与ST131-H30R携带之间的关联.

主要成果:

携带ST131-H30R的参与者在基线时显示出更多的Actinobacteria和Collinsella,以及较少的Alistipes.
纵向分析显示,科林塞拉的丰富性与ST131-H30R携带有正相关,与其损失有负相关.
菌种的丰富性与ST131-H30R的丢失和缺失有关,即使家庭暴露.

结论:

特定的便细菌丰度与ST131-H30R携带,持久性和清除有关.
这些肠道细菌可能成为基于微生物的干预措施的潜在目标,以减少ST131-H30R携带.
减少ST131-H30R携带至关重要,因为它是侵入性感染的重要风险因素.

关键词:

这是Alistipes的类型.科林塞拉科林塞拉科林塞拉埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.我们的肠道微生物组.在H30R中,它是H30R.ST131 一个人的生活

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