土耳其儿童和青少年的视神经炎:一个多中心的回顾性研究
Meltem Çobanoğulları Direk1, Şeyda Besen2, İbrahim Öncel3
1Department of Pediatrics, Division of Pediatric Neurology, Mersin University Faculty of Medicine, Faculty Of Medicine, 34, Cadde, Çiftlikköy Kampüsü, Mersin 33343, Türkiye.
Multiple sclerosis and related disorders
|December 14, 2023
概括
儿童自身免疫性视神经炎的呈现因年龄而异,年龄较大的儿童更有可能患上多发性硬化症. 虽然大多数患者会康复,但复发形式和与水素-4抗体相关的视神经炎表明预后不太好.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性疾病越来越多地被认为是视神经炎的原因.
- 了解儿科自身免疫视神经炎的人口,临床和预后因素至关重要.
研究的目的:
- 重新检查儿童自身免疫视神经炎的人口,临床,实验室特征和预后因素.
- 基于对自身抗体介导疾病的当前知识,更新对自身抗体介导疾病的理解.
主要方法:
- 来自土耳其27个中心的儿科视神经炎病例的回顾性评估 (2009-2022年).
- 对279名患者的分析,按年龄分类 (青春期前与其他).
- 对诊断,复发,治疗和12个月后的结果进行评估.
主要成果:
- 多发性硬化症相关的视神经炎最常见于年龄较大的儿童 (≥10岁).
- 与髓寡腺细胞糖蛋白抗体相关的视神经炎在青春期前儿童 (10岁以下) 中占主导地位.
- 24%的患者出现复发,女性更频繁;88.5%的患者在12个月内完全康复.
结论:
- 视神经炎的横向性因年龄而异:在青春期前是双边的,在年长的儿童中是单边的.
- 年龄≥10岁,橄克隆带和头骨MRI病变预测多发性硬化症的发展.
- 复发性视神经炎和AQP4-IgG相关的视神经炎的预后较差,需要进一步研究.
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