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通过预视眼谷氨酸神经元调节压力诱导的睡眠碎片化

Jennifer Smith¹, Adam Honig-Frand¹, Hanna Antila¹

¹Department of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Current biology : CB

|December 14, 2023

概括

压力事件通过引起微刺激 (MAs) 来扰乱睡眠. 研究人员发现,特定的下丘脑神经元控制MA,影响睡眠质量,并为睡眠障碍治疗提供新的点.

科学领域:

神经科学是一个神经科学.
睡眠科学睡眠科学
行为生物学行为生物学

背景情况:

睡眠障碍会对行为和情绪健康产生负面影响.
压力事件通过诱导微刺激 (MAs) 来破坏睡眠.
下丘脑的前视区域 (POA) 对于睡眠调节至关重要,但其在MAs中的作用尚不清楚.

研究的目的:

研究POA神经元在调节微刺激 (MAs) 和睡眠质量的作用.
了解压力如何影响POA神经元活动和睡眠碎片化.
为了识别控制MAs和睡眠巩固的神经回路.

主要方法:

在小鼠中进行纤维光度测量,以监测睡眠期间遗传定义的POA神经元活动.
光遗传学操纵以刺激或抑制特定的神经元群体.
单突触限制狂犬病追踪用于映射神经输入到POA神经元.
急性社会失败压力范式诱导睡眠碎片化.

主要成果:

在非快速眼动睡眠 (NREM) 期间,POA质神经元表现出节奏活动,并在MA期间暂时激活.
这些神经元的光遗传刺激会增加MA和清醒度.
在NREM期间,社会压力会增加MA和POA的谷氨酸性神经元活动.
抑制POA谷氨酸性神经元巩固NREM,自发和应激后减少MA.
压力激活的横向下丘脑神经元向POA投射,并在刺激时促进MA.

结论:

POA质神经元是微兴奋和睡眠质量的关键调节者.
压力诱导的POA神经元的激活有助于睡眠碎片化.
准POA-侧向下丘脑电路为治疗与压力相关的睡眠障碍提供了一个潜在的策略.

关键词:

红外缓慢的节奏.微小的,微小的.前光学区域的前光学区域.睡眠睡眠睡眠睡眠睡眠压力就是压力,压力就是压力.

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