在明尼苏达州信任游戏中对精神病中不顾敏感性的价值表示
Rebecca Kazinka1, Anita N D Kwashie2, Danielle N Pratt3
1Department of Psychology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|December 14, 2023
概括
这项研究揭示了轨道前皮层岛和前面对面网络之间的大脑连接减少与精神病中的迫害思想和不顾敏感性增加有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 尽管敏感性是理解迫害思想及其神经基础的关键构造.
- 需要进行研究,以探索迫害与精神病中的不顾敏感性之间的关系.
研究的目的:
- 调查精神病患者中迫害思想和恶意敏感性之间的关系背后的神经基质.
主要方法:
- 49名患有精神病的参与者在玩明尼苏达信任游戏时接受了功能磁共振成像 (fMRI).
- 行为测量包括不信任,迫害思想 (使用简要精神病学评分表) 和计算建模.
- fMRI分析了功能连接和血液氧气水平依赖 (BOLD) 激活在预定义的大脑区域在恶意敏感的决策.
主要成果:
- 具有较高迫害思想的个人表现出较少的信任,特别是在旨在引起怀疑的条件下.
- 轨道前皮层岛屿和左侧前双面网络之间的功能连接性下降与增加的迫害思想和反感敏感性相关.
- 在不同的游戏条件下,在尾状核,中间前额叶皮质和侧轨前额叶皮质中观察到不同的激活模式.
结论:
- 这些发现确定了连接恶意敏感和迫害思想的特定大脑电路.
- 这项研究为精神病中积极症状的神经起源提供了新的见解.
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