模拟透析表现型与儿科高性心肌病的结果之间的关系
Minh B Nguyen1, Maelys Venet2, Chun-Po Steve Fan3
1Department of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas; Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
概括
儿科超性心肌病 (HCM) 的透气功能障碍与不良事件有关. 左心房大小,调整为身体表面积,独立预测这些孩子的不良结果.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管成像 - 心血管成像
- 遗传心脏病学 遗传心脏病学
背景情况:
- 儿科超性心肌病 (HCM) 携带不良事件的风险.
- 扩张性功能障碍在儿科HCM结局中的作用尚不清楚.
- 这项研究调查了腹筋表型与儿科HCM的不良事件之间的关联.
研究的目的:
- 探讨患有HCM的儿科患者的扩张性功能障碍和主要心脏不良事件 (MACE) 之间的关联.
- 在这个人群中确定预测MACE的关键心声学参数.
- 了解扩张功能对儿科HCM不良结果的贡献.
主要方法:
- 在儿科HCM患者中对心声回声透气功能参数的主要组成部分分析.
- 主要组件的回归分析与免于MACE.
- 在MACE中,包括ICD插入,肌切除术,堕胎的SCD,移植,机械支或死亡.
主要成果:
- 调整为身体表面积的左心房大小参数与MACE独立相关 (HR,0.69;95% CI,0.5-0.94).
- 左心室填充压力变量与MACE有关联,但在调整左心室厚度和遗传变异后,这并不显著.
- 最终的对共变量调整的模型显示了MACE的强有力的预测性能 (一致性指数,0.82).
结论:
- 扩张性功能障碍参数,左心室缩严重程度和遗传变异与儿科HCM中的MACE有关.
- 根据身体表面积调整的左心房大小是不良事件的独立预测指标.
- 对大小调整的透支功能参数的进一步研究可能会改善儿科HCM的不良事件预测.
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