暴露于低环境温度会增加缺血性中风的风险,因为它促进了血小板激活
Zhuangzhuang Chen1, Peilin Liu1, Xiaoshuang Xia2
1Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China.
The Science of the total environment
|December 14, 2023
概括
低环境温度增加血小板激活,这是缺血性中风的关键因素. 这项研究将寒冷的天气与通过增强的血小板聚合而增加的中风风险联系在一起,特别是在老年男性和高血压患者中.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 血液学 血液学 血液学
背景情况:
- 流行病学研究将低环境温度与缺血性中风风险增加联系起来.
- 连接暴露于寒冷和中风病原体的潜在机制需要阐明.
研究的目的:
- 研究环境温度对血小板激活的影响.
- 利用多中心临床数据和动物模型来探索温度 - 血栓形成的联系.
主要方法:
- 对约3000名缺血性中风患者的血小板聚合率和气象数据 (2018-2020) 的分析.
- 一般化添加剂混合模型 (GAMM) 用于评估温度-血小板聚合相关性.
- 在体内和体外动物实验中,在暴露于寒冷条件下评估了血小板功能,血液静止和血栓形成.
主要成果:
- 观察到一种非线性关系:平均温度下降1°C与血小板聚合增加7.77%相关.
- 男性,65岁以上的个体和高血压患者表现出更高的敏感性.
- 寒冷暴露诱导的血小板激活与动物模型中增加的CIRBP和p-AKT/p-ERK信号相关.
结论:
- 暴露在低环境温度下可能会强化血小板激活.
- 研究结果提供了有关温度在脑血管疾病发展中的作用的机制性见解.
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