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Updated: Jul 8, 2025

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唾液中循环miRNA的稳定性:与样本相关的预分析变量的影响

Chiara Romani1, Maria Baronchelli2, Claudia Assoni2

  • 1Angelo Nocivelli Institute of Molecular Medicine, ASST Spedali Civili of Brescia, Brescia, Italy; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy.

Clinica chimica acta; international journal of clinical chemistry
|December 14, 2023
PubMed
概括

没有唾液细胞的微RNA (cf-miRNAs) 是有前途的癌症生物标志物. 最佳的收集和储存条件确保cf-miRNA稳定性,可靠的临床使用.

关键词:
没有细胞的miRNA.液体活检液体活检口腔癌是一种口腔癌.在分析前的可变性.这是唾液.

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RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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