严重COVID-19的风险和疫苗接种的保护性有效性在固体器官移植接受者中
Kyungmin Huh1, Minsun Kang2, Young-Eun Kim3
1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
The Journal of infectious diseases
|December 14, 2023
概括
固体器官移植接受者 (SOTRs) 面临严重COVID-19的更高风险. 接种疫苗显著降低了这种风险,突出了提高这一脆弱人群接种疫苗的必要性.
科学领域:
- 移植医学 移植医学
- 传染病流行病学 传染病流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 固体器官移植接受者 (SOTRs) 免疫力低下,患重症感染的风险增加.
- 严重的COVID-19的特定风险和在SOTR中COVID-19疫苗接种的有效性尚未确立.
研究的目的:
- 为了评估SOTRs与非SOTRs相比,SOTRs中严重COVID-19的风险.
- 评估COVID-19疫苗接种在预防SOTRs中严重疾病的有效性.
主要方法:
- 韩国 (2020-2022) 全国医疗保健索赔数据库和COVID-19注册表的回顾性分析.
- 成人SOTRs与COVID-19与非SOTRCOVID-19患者的倾向性得分匹配.
- 严重的COVID-19的定义包括需要高流量鼻管,机械通风或ECMO.
主要成果:
- 与非SOTRs相比,COVID-19的SOTRs具有明显更高的严重疾病风险.
- 肺移植接受者表现出严重COVID-19的最高风险 (aOR 18.14).
- 在SOTR中,针对严重的COVID-19的疫苗有效率为47% (2剂),64% (3剂) 和64% (4剂).
结论:
- SOTRs面临严重COVID-19的风险大幅增加.
- 在SOTRs.中,COVID-19疫苗接种在减轻严重疾病进展方面表现出有效性.
- 提高SOTR疫苗接种率和实施额外的保护措施的战略至关重要.
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