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在酒精依赖的老鼠中,psilocybin诱导的默认模式网络低连接性被削弱

Jonathan R Reinwald^1,2,3, Christian N Schmitz^2,4, Ivan Skorodumov⁵

¹Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.

Translational psychiatry

|December 14, 2023

概括

西显示出酒精使用障碍 (AUD) 治疗的潜力,但严重的AUD病例可能需要更高的剂量. 这项研究发现,酒精复发的强度与大脑对psilocybin的反应减少有关.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
精神病学是一个精神病学.

背景情况:

酒精使用障碍 (AUD) 影响全球数百万人,有效治疗方法有限.
псилоцибин对AUD有希望,但其作用机制和AUD患者的大脑反应尚未完全理解.

研究的目的:

为了研究psilocybin对健康大鼠的大脑连接的作用和酒精复发的老鼠模型.
为了探索AUD特异性改变大脑对psilocybin的反应性.

主要方法:

一个随机的,安慰剂控制的交叉药物fMRI研究在老鼠.
休息状态功能连接,默认模式网络 (DMN) 连接和的分析.

主要成果:

西降低了广泛的功能连接性,但增加了神经和皮质区域之间的连接性.
观察到西诱导的DMN低连接性的翻译证据.
与酒精复发强度相关的DMN低连接性的AUD特异性化.

结论:

西在动物中诱导了急性神经效应,对人类具有翻译有效性.
神经对西的反应性与酒精复发的严重程度有负相关性.
在严重的AUD病例中,标准的psilocybin剂量可能不足,这为未来的临床试验设计提供了信息.

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