在吸烟行为中预测和分层化慢性阻塞性肺病的纵向风险
Yixuan He1,2,3, David C Qian4, James A Diao5
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Nature communications
|December 14, 2023
概括
环境和社会经济因素显著增加慢性阻塞性肺病 (COPD) 的风险,即使在从不吸烟的人. 一个新的风险评分突出了除了吸烟状态之外的这些因素,以更好地预测COPD.
科学领域:
- 肺部病理学 肺部病理学
- 环境健康 环境健康
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,吸烟是慢性阻塞性肺病 (COPD) 的首要危险因素.
- 许多从未吸烟的人也会患上COPD,这表明了其他因素.
研究的目的:
- 开发和验证一种新的风险评分,量化除了吸烟之外的累积环境,行为和社会经济暴露.
- 评估这一COPD事件风险评分的预测能力.
主要方法:
- 在英国生物银行队列中对COPD病例的纵向分析.
- 发展和验证社会经济和环境风险评分 (SEERS).
- 与吸烟状态和包装年相比,SEERS预测准确度的比较.
主要成果:
- 在SEERS中,COPD的预测准确度高于吸烟状态和包装年份.
- 在SEERS的最高十分位数中的个人表现出发生COPD的风险大幅增加.
- 暴露风险最高的从未吸烟者比低风险的吸烟者更容易患上COPD.
结论:
- 环境和社会经济因素是COPD发展的关键,独立因素.
- SEERS提供了一种更全面的方法来识别患有COPD高风险的个人,特别是非吸烟者.
- 需要进一步的研究来优化SEERS对不同人群的优化,因为在非欧洲人群中准确性较低.
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