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Updated: Jul 8, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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PACT - 通过线程预测粉样蛋白交叉相互作用

Jakub W Wojciechowski1, Witold Szczurek2, Natalia Szulc2,3,4

  • 1Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, 50-370, Wrocław, Poland. jakub.wojciechowski@pwr.edu.pl.

Scientific reports
|December 14, 2023
PubMed
概括

一种新的计算方法,PACT,可以预测不同物种的粉样蛋白之间的相互作用. 该工具有助于了解粉样蛋白疾病和微生物粉样蛋白对人类健康的影响,并对细菌CsgA和人类蛋白质进行实验验证.

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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