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在cuprizone模型中,内源性Sox8是及时复髓化和寡基质细胞补充的关键因素

David Freudenstein1, Magdalena Lippert1, Janina Sophie Popp1

  • 1Neuroimmunology Laboratory, Department of Neurology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Scientific reports
|December 14, 2023
PubMed
概括

转录因子Sox8在髓维护中起着至关重要的作用. 在多发性硬化症模型中,小鼠的Sox8缺乏会显著延迟复髓化,这突显了它在髓修复中的重要性.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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