系统性炎症标志物与高血压患病率之间的关联
Nake Jin1, Lei Huang2, Jun Hong1
1Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, 315336, China.
BMC cardiovascular disorders
|December 15, 2023
概括
系统性炎症标志物,包括系统性免疫炎症指数 (SII),系统炎症反应指数 (SIRI) 和系统性炎症总指数 (AISI),与高血压患病率有关. 这些标记物可能有助于早期检测高血压.
科学领域:
- 流行病学 流行病学
- 心血管健康 心血管健康
- 生物标志物 生物标志物
背景情况:
- 系统性炎症与各种慢性疾病有关.
- 确定高血压的可靠生物标志物对于早期检测和管理至关重要.
研究的目的:
- 调查系统性炎症标志物与高血压患病率之间的关联.
- 探索SII,SIRI和AISI作为早期高血压生物标志物的潜力.
主要方法:
- 采用了国家健康和营养检查调查中119,664人的数据进行的横截面研究.
- 分析系统性免疫炎症指数 (SII),系统炎症反应指数 (SIRI),系统炎症综合指数 (AISI) 和高血压患病率之间的关联.
主要成果:
- 高血压的患病率在logSII,logSIRI和logAISI的四分位数较高时增加.
- 每个单位的logSII,logSIRI和logAISI的增加,分别与20.3%,20.1%和23.7%的高血压风险增加相关.
- 限制立方线分析表明非线性关系,高标记与高血压患病率增加有关.
结论:
- 在SII,SIRI,AISI和高血压患病率之间观察到显著的正相关性.
- 这些系统性炎症指数显示为早期高血压检测的潜在生物标志物具有前途.
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