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Updated: Jul 8, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
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细胞衰老通过调节p53信号通路的上升,有助于机械通风引起的隔膜功能障碍

Weimin Shen1, Ye Jiang1, Ying Xu1

  • 1Department of Respiratory Care, Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Qingchun East Rd. 3, Hangzhou, 310016, China.

BMC pulmonary medicine
|December 15, 2023
PubMed
概括

机械通风导致隔膜缩和功能障碍. 这项研究发现,p53依赖的细胞衰老在这种通风诱导的隔膜功能障碍 (VIDD) 中起着作用,这表明了新的治疗点.

关键词:
细胞衰老 细胞衰老隔膜功能障碍 隔膜功能障碍机械通风机械通风机械通风机在 p53-p21 轴上

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