辅助生殖技术导致不同的二次性别比率:父母和胚胎的影响
Jiansen Zhao1, Haoran Shen2, Qijiong Zhu3
1Nanshan School, Guangzhou Medical University, Guangzhou, 511436, China.
Reproductive health
|December 15, 2023
概括
辅助生殖技术 (ART) 影响出生时的性别比. 父亲年龄,胚胎移植类型和淋巴激素使用时间等因素显著影响ART怀孕中的二次性别比率 (SSR) 结果.
科学领域:
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
- 生物统计学 生物统计学
背景情况:
- 辅助生殖技术 (ART) 已经进步,促使研究其对二次性别比率 (SSR) 的影响,即出生时男性与女性的比例.
- 了解影响SSR的因素对于生殖咨询和ART优化至关重要.
研究的目的:
- 调查影响单独生育,双胞胎怀孕的单独生育和双胞胎怀孕的双胞胎二次性别比率 (SSR) 的父母和胚胎因素.
- 确定特定的ART参数和与SSR变异相关的患者特征.
主要方法:
- 追溯分析了来自6,223对接受ART的8,335例分娩.
- 用于单子和双胞胎怀孕的单子的二元逻辑回归.
- 在双胞胎怀孕中使用双胞胎的多项逻辑回归模型.
主要成果:
- 增加的SSR与二次不孕症,晚年父亲年龄和胚胎细胞移植有关;冷胚胎移植 (FET) 与单独生子的SSR降低有关.
- 较长的淋巴激素 (Gn) 持续时间降低了单子和双胞胎妊娠的单子的SSR.
- 诸如男性诱导的不孕症,较高的Gn剂量,较长的孕妇年龄和细胞内精子注射 (ICSI) 等因素影响了双胞胎怀孕中单生子的SSR. 父亲的年龄和Gn剂量影响了双胞胎的性别比例;切割阶段转移增加了男孩和女孩双胞胎的比例.
结论:
- ART的结果表明影响SSR的因素的复杂相互作用,包括不孕症类型,父亲年龄,受精方法,胚胎移植阶段和GN使用时间.
- 需要进一步的大规模研究来验证和扩展有关ART和SSR的这些发现.
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