微生物群在E. tenella感染期间促进白内障巨细胞的招募和促炎反应
Gut pathogens
|December 15, 2023
概括
肠道微生物群对于在中感染Eimeria tenella时招募和激活白内障巨是必不可少的. 调节这种微生物群可以通过控制炎症来减少疾病的严重程度.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 埃梅里亚氏菌会引起菌病,这是家禽中昂贵的肠道疾病.
- 体微生物群影响Eimeria tenella感染严重程度的机制以前是未知的.
- 巨细胞是关键的炎症细胞,它们在微生物群和E. tenella相互作用中的作用尚未研究.
研究的目的:
- 为了研究白内障微生物群在中Eimeria tenella感染期间对巨细胞行为的影响.
- 阐明巨细胞在微生物群和寄生虫诱导的病理之间的相互作用中的作用.
主要方法:
- 毛囊组织的免疫光染色用于监测巨细胞 (KUL01抗体).
- 从无菌和常规中分离,染色和分类白内障细胞.
- 高通量qPCR用于分析经过排序的白内障细胞中的基因表达.
主要成果:
- 微生物群对于在E. tenella感染期间招募白内障巨细胞至关重要.
- 微生物群促进了亲炎性巨细胞的特征,主要炎症基因 (NOS2,TNFα,IL1β等) 的表达升高表明了这一点. ) 的情况.
- 将微生物群转移到无菌中,部分恢复了巨细胞的招募和反应.
结论:
- 肠道微生物群通过增强巨细胞的招募和激活来加剧Eimeria tenella感染.
- 准肠道微生物群调节可能是减轻巨细胞驱动炎症和减轻疾病后果的策略.
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