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营养状况与血造干细胞移植候选人的生物化学标记之间的关联:一个横截面研究
Hoda Zahedi1, Sayeh Parkhideh1, Omid Sadeghi2
1Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC nutrition
|December 15, 2023
概括
具有营养风险的血造干细胞移植 (HSCT) 候选人表现出较高的炎症标志物和较低的BMI. 使用BMI和生化标志物的营养状况评估对这些患者至关重要.
科学领域:
- 血液学 血液学 血液学
- 临床营养学 临床营养学
- 生物化学 生化学
背景情况:
- 血造干细胞移植 (HSCT) 候选人面临营养挑战,包括摄入量减少,需求增加和吸收不良.
- 早期识别营养风险对于HSCT患者的治疗结果至关重要.
研究的目的:
- 在HSCT候选人中研究营养状况和血液生物标志物之间的关系.
- 确定可靠的指标,以评估这一群体的营养风险.
主要方法:
- 在278名HSCT候选人中,使用营养风险查工具 (NRS-2002) 评估了营养状况.
- 测量了血液生物标志物,包括C反应蛋白 (CRP),红细胞沉积率 (ESR),血红蛋白,白蛋白,总蛋白,CRP-白蛋白比率 (CAR) 和体重指数 (BMI).
- 根据NRS-2002得分对患者进行分类,以比较生物标志物水平.
主要成果:
- 营养不良的患者 (NRS-2002 ≥3) 呈现明显升高的炎症标志物 (ESR,CRP,CAR).
- 低体重指数 (BMI),血清白蛋白和血红蛋白度在营养不良的个体中被观察到.
- 经过对混因素进行调整后,总蛋白质水平与营养状况没有显著的关联.
结论:
- 身体质量指数 (BMI) 和特定的生化标志物对于评估HSCT候选人的营养状况是有效的.
- 营养状况被证明与接受HSCT的患者的全身炎症有关.
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