Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

23.5K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
23.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.

Cell biochemistry and function·2026
Same author

Exploring the Challenges and Legal Implications of Secondary Use of Health Data in South Africa.

Developing world bioethics·2026
Same author

Protocol: A multi-factorial, multi-centre study, for biomarker identification in healthy controls for comparison to babies with moderate-severe NESHIE.

PloS one·2026
Same author

Increasing Access to Pediatric Allogeneic Hematopoietic Stem Cell Transplantation in South Africa.

Pediatric blood & cancer·2026
Same author

Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

An epigenetic perspective on neonatal encephalopathy with suspected hypoxic ischaemic encephalopathy.

Clinical epigenetics·2025

相关实验视频

Updated: Jul 8, 2025

Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

7.9K

在体外增强间酶体 stromal/干细胞肌源性承诺的考虑因素.

Simone Grobbelaar1,2, Anne E Mercier1, Iman van den Bout1,3

  • 1Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Clinical and translational science
|December 15, 2023
PubMed
概括

介质干细胞 (MSCs) 可以被引导形成肌肉组织. 本综述探讨了诸如化学诱导剂和机械刺激等体外方法,以改善MSC肌源性差异化,用于再生医学应用.

更多相关视频

Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

1.1K
In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

10.9K

相关实验视频

Last Updated: Jul 8, 2025

Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

7.9K
Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

1.1K
In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

10.9K

科学领域:

  • 生物医学工程 生物医学工程
  • 干细胞生物学 干细胞生物学
  • 再生医学是一种再生医学.

背景情况:

  • 介酶体 stromal/干细胞 (MSCs) 是具有再生医学潜力的多能细胞.
  • MSCs可以分化为各种血统,包括脂肪性,骨质性,软质性和肌质性.
  • 与其他血统相比,MSCs的肌源性差异化研究较少.

研究的目的:

  • 审查体外策略,以增强介质干细胞 (MSC) 差异化进入肌源性血统.
  • 探索化学,基质和机械/动态培养条件,以获得肌源性承诺.
  • 为改善MSC肌原分化的机制和信号通路提供见解.

主要方法:

  • 对MSC肌原分化的体外策略的文献综述.
  • 化学诱导剂,细胞培养基质和机械/动态培养的分析.
  • 检查从胚胎和产后肌形成的机制.

主要成果:

  • 各种化学和机械刺激可以促进MSC肌原分化.
  • 了解基因和信号级联对于监测差异化至关重要.
  • 具体的策略可以提高MSC肌源性承诺的有效性.

结论:

  • 优化体外条件是改善MSC肌原分化的关键.
  • 对刺激和信号通路的进一步研究将推动临床翻译.
  • 增强的MSC肌原分化对治疗应用具有前景.