侧面和背侧面桃体参与条件刺激模式依赖于大鼠的双向回避表现
1Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland, Email: tomek@nencki.gov.pl. None.
Acta neurobiologiae experimentalis
|December 15, 2023
概括
患有杏仁体病变的老鼠显示,避免学习和表现受损. 这些大脑区域对于处理警告信号和在避免训练期间巩固学到的关联至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 学习和记忆的学习和记忆
背景情况:
- 杏仁体在恐惧调节和情绪学习中起着至关重要的作用.
- 了解杏仁体子区域在复杂的学习任务中的具体作用是必不可少的.
研究的目的:
- 调查侧面和结合的背侧面桃体/桃体三角体过渡区域病变对穿箱避开学习和转移的影响.
- 检查这些杏仁体区域在处理不同模式的警告信号 (CSs) 中的参与.
主要方法:
- 在大鼠中,电解损伤诱导了侧面桃体 (LAT) 或联合桃体-桃体过渡区域和背侧桃体 (D-LAT).
- 伪造的病变作为对照 (NORM).
- 鼠被训练在一个穿箱避开任务与视觉和听觉警告信号,与不同的序列来评估转移.
主要成果:
- D-LAT大鼠表现出明显受损和不一致的回避行为.
- 拉特老鼠表现出轻微的学习缺陷,但信号传输没有缺陷.
- 两组受伤者表现出独立于警告信号模式变化的表现,与对照组不同.
结论:
- 侧面桃体和结合的背侧桃体/桃体-桃体过渡区域在处理警告信号方面有所不同.
- 这些杏仁体区域对于在避免学习过程中形成的关联的巩固至关重要.
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