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Updated: Jul 8, 2025

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
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Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

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开发一种小鼠胚胎干细胞模型,用于研究链接基因组 H1-4 的功能

Abed Alkarem Abu Alhaija1,2, Imtiaz Nisar Lone2, Esin Ozkuru Sekeroglu2,3

  • 1Department of Molecular Biology and Genetics, Faculty of Basic Sciences, Gebze Technical University, Turkey.

FEBS open bio
|December 15, 2023
PubMed
概括

研究人员创造了人工小鼠干细胞来研究拉赫曼综合征,这是一种与H1.4基因突变相关的神经疾病. 这些细胞有助于了解H1.4蛋白的功能和疾病机制.

关键词:
这就是CRISPR/Cas9的作用.H1.4 时间表 H1.4拉赫曼综合征是什么 拉赫曼综合征细胞模型的细胞模型.链接器 基因组 基因组在 mES 细胞中.

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Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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