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与神经外科植入物相关的伤口感染的治疗
Yu Wang1, Yuhao Wang1, Shuai Wang1
1Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, China.
International wound journal
|December 15, 2023
概括
神经外科植入物感染,通常是由生物膜引起的,增加了发病率和死亡率. 结合手术和抗生素的方法,包括优化诊断和长期的抗菌疗法,对于有效的治疗至关重要.
科学领域:
- 神经外科 神经外科
- 传染性疾病 传染性疾病
- 生物材料科学 生物材料科学
背景情况:
- 神经外科植入物越来越多地用于伴随疾病的老年患者,导致植入物相关感染的增加.
- 这些感染导致显著的发病率和死亡率,涉及诸如头骨异常和大脑保护不足等并发症.
- 由皮肤植物等微生物形成的生物膜是这些感染的核心,对其去除构成了挑战.
研究的目的:
- 审查和讨论与各种神经外科植入物相关的感染,包括脑脊液排水,神经刺激器和部植入物.
- 检查其他外科领域治疗生物膜相关感染的既定原则,以及它们对神经外科手术的潜在推断.
- 突出了对神经外科植入物感染的优化诊断和治疗策略的需要.
主要方法:
- 对其他外科专业中神经外科植入物感染和生物膜相关感染的文献综述.
- 讨论诊断方法,包括超声波植入物和延长培养化.
- 对结合手术除菌,植入物管理和长期抗微生物治疗的治疗策略的分析.
主要成果:
- 神经外科植入物感染主要是由在手术期间或手术后不久进入的微生物引起的,在大多数患者中早期表现.
- 植入物上的生物膜形成是关键因素,使得感染难以治疗.
- 虽然骨科和创伤外科手术的原则存在,但它们在神经外科手术中的成功证据有限.
结论:
- 神经外科植入物感染的有效管理需要一个最佳的微生物学诊断和一个结合的手术-抗生素方法.
- 外科干预可能涉及脱bridement和植入物替换/交换,而抗菌药物治疗应该延长 (4-12周).
- 植入物更换或保留的单阶段手术程序,结合适当的抗菌药物治疗,可以改善患者的生活质量并降低发病率.
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