长期COVID背后的内在因素:第三. SARS-CoV-2及其组成部分的持久性
Nawal Abd El-Baky1, Amro A Amara1, Vladimir N Uversky2
1Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Egypt.
Journal of cellular biochemistry
|December 15, 2023
概括
在组织中持续存在的SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 是长期COVID的关键因素. 这种病毒的持久性,在最初感染后很长时间被检测出来,导致持续的健康问题和免疫后果.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 关于SARS-CoV-2感染和免疫反应的研究广泛,但SARS-CoV-2感染 (PASC) 或长期COVID的后急性后果背后的机制仍在争论中.
- 在急性SARS-CoV-2感染后报告了许多长期症状,但关于其原因和分子基础的证据有限.
研究的目的:
- 审查SARS-CoV-2持久性及其组成部分作为导致长期COVID的内在因素的作用.
- 要突出与宿主组织中持续存在的SARS-CoV-2相关的免疫后果.
主要方法:
- 关于SARS-CoV-2在各种宿主组织中的持久性现有研究文献的审查.
- 对报告检测SARS-CoV-2RNA和蛋白质在死后和活检样本中的研究分析.
- 检查病毒复制的证据及其对免疫反应的影响.
主要成果:
- 在多个非呼吸组织中检测到SARS-CoV-2和/或其成分,包括皮肤,尾,乳腺,上腺,眼组织,小肠,淋巴结,心肌和坐骨神经.
- 持续的病毒RNA,包括近期复制的亚基因组RNA,已在各种组织中发现,有时在症状出现几个月后.
- 在尸体解剖时,在严重的未接种疫苗的病例中,在症状出现后的230天内,已经在大脑中检测到病毒RNA.
结论:
- 宿主组织中SARS-CoV-2的持久性是推动长期COVID发展的重要内在因素.
- 病毒的持续性可能会引发或加剧免疫功能障碍,导致长期COVID患者观察到的多样化和长期症状.
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