[肠道微生物群和自闭症谱系障碍:对治疗干预的相关性和潜在影响的概述]
Johanna Neubauer1, Anna Kaiser1,2, Sarah Hohmann1,3
1Klinik für Kinder- und Jugendpsychiatrie, -psychiotherapie und -psychosomatik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
|December 15, 2023
概括
研究表明,自闭症谱系障碍 (ASD) 患者的肠道微生物群组成存在差异. 探索大脑-肠-微生物轴为ASD提供了潜在的治疗策略.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 微生物组研究 微生物组研究
- 神经精神疾病 神经精神疾病
背景情况:
- 从历史上看,肠道微生物群的研究主要集中在胃肠道疾病上.
- 新出现的证据将肠道微生物群失调与神经精神疾病联系起来,包括自闭症谱系障碍 (ASD).
- 大脑 - 肠道 - 微生物组轴是一个关键的途径,涉及到这些相关性.
研究的目的:
- 审查肠道微生物群与自闭症谱系障碍之间的相关性.
- 探索针对ASD的肠道微生物群的潜在治疗干预措施.
- 突出现有领域的理解和局限性.
主要方法:
- 审查关于肠道微生物群和ASD的现有文献.
- 对研究大脑-肠-微生物组轴在ASD中的研究分析.
- 检查拟议的治疗策略.
主要成果:
- 与神经类型对照人群相比,在ASD患者中经常观察到肠道微生物组合的改变.
- 假设大脑-肠-微生物群轴调解肠道微生物群对ASD大脑功能和行为的影响.
- 具体的机制在很大程度上是未知的,阻碍了最终的治疗结论.
结论:
- 肠道微生物群的改变与ASD相关,可能通过脑-肠-微生物群轴影响大脑功能.
- 有前途的治疗途径包括饮食修改,益生菌,益生菌和便微生物群移植.
- 进一步进行高质量的临床研究对于阐明ASD病理生理学和完善诊断和治疗方法至关重要.
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