关于发现针对临床相关病原体的抗定数感应剂的文献分析:当前状态,发展和未来方向
Bo Peng1, Yanqun Li2,3, Jiajia Yin2,3
1Institute for Environmental and Climate Research, Jinan University, Guangzhou, China.
Frontiers in microbiology
|December 15, 2023
概括
反定数感应剂 (anti-QSA) 通过破坏细菌通信来对抗耐药性感染. 研究显示,人们正在转向纳米材料,天然产品和人工智能,这表明未来抗生物膜和抗病毒药物开发的热点.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 药物发现 药物发现 药物发现
背景情况:
- 定数感应 (QS) 是细菌细胞对细胞的通信,调节群体行为.
- 抗QS剂 (anti-QSA) 提供了一种打击抗生素耐药性和治疗感染的策略.
- 本研究分析了针对临床相关病原体的抗QSA的全球研究趋势.
研究的目的:
- 分析反QSA研究的输出,热点和趋势.
- 确定新兴的研究前沿和该领域的关键概念.
- 为了指导未来的反QSA开发研究方向.
主要方法:
- 从科学网络核心收藏中对1998-2023年出版物的图书统计分析.
- 使用CiteSpace和Alluvial Generator进行可视化和解释.
- 分析出版成果,有影响力的国家,作者,期刊,关键词和研究领域.
主要成果:
- 反QSA研究的快速增长,有1743篇出版物.
- 美国在贡献和影响力方面处于领先地位.
- 研究前沿已经转向材料科学,天然产品和人工智能,重点关注抗生物膜/抗病毒策略.
- 关键的概念包括大肠杆菌,假龙,毒性因子,细菌生物膜和基因表达.
结论:
- 反QSA研究正在迅速发展,具有显著的增长和转移的重点.
- 纳米材料,海洋天然产品和人工智能被确定为潜在的未来研究热点.
- 这种文献计量分析为研究人员提供了洞察力,以确定反QSA发展的新兴趋势和新途径.
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