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急性暴露于柴油颗粒物会促进甲状腺癌细胞中的集体细胞迁移

Sheena Yi-Hsin Cheng¹, Shih-Yuan Huang², Shih-Ping Cheng^2,3,4

¹Taipei European School, Taipei, Taiwan.

Frontiers in toxicology

|December 15, 2023

概括

细颗粒物,空气污染的一个组成部分,改变了甲状腺癌细胞的行为. 它促进了集体细胞迁移和改变了细胞形态,表明了与癌症进展的潜在联系.

科学领域:

环境健康环境健康
癌症生物学癌症生物学
细胞毒理学细胞毒理学

背景情况:

生态研究表明,环境空气污染与甲状腺癌发病率之间存在相关性.
细颗粒物 (PM) 是空气污染的主要组成部分,具有潜在的健康影响.

研究的目的:

为了研究细颗粒物对人类甲状腺癌细胞系的影响.
确定PM暴露是否影响细胞生长,形态和迁移.

主要方法:

人类甲状腺癌细胞系 (8505C和TPC-1) 暴露于经过认证的柴油颗粒物 (NIST1650b).
进行了功能性测试,包括细胞生长,殖民地形成,伤口愈合和跨井迁移测试.
在PM治疗后观察到细胞形态变化.

主要成果:

NIST1650b没有显著影响短期细胞生长,但在高度下降了殖民地形成.
暴露于颗粒物诱导了细胞形态的改变,以集群凝聚为特征.
伤口愈合试验显示,在10微克/毫升PM的两种细胞系中,伤口关闭显著增加.
在8505C细胞中观察到对细胞迁移的微弱刺激作用.

结论:

暴露于细颗粒物可以诱导甲状腺癌细胞中的连贯细胞表型.
暴露于PM增加了集体细胞迁移,这表明它可能在甲状腺癌的进展中发挥作用.
这些发现凸显了空气污染对甲状腺癌攻击性的潜在影响.

关键词:

伤口愈合试验试验空气污染空气污染集体细胞迁移集体细胞迁移微细颗粒物质的细颗粒物质的细颗粒物质的细颗粒物质的细颗粒物质.甲状腺癌是一种癌症.

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